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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLEK
All Species:
32.12
Human Site:
S231
Identified Species:
70.67
UniProt:
P08567
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08567
NP_002655.2
350
40097
S231
F
F
C
E
E
N
S
S
D
D
D
V
I
L
K
Chimpanzee
Pan troglodytes
XP_515524
350
40124
S231
F
F
C
E
E
N
S
S
D
D
D
V
I
L
K
Rhesus Macaque
Macaca mulatta
XP_001094492
350
40060
S231
F
F
C
E
E
N
S
S
D
D
D
V
I
L
K
Dog
Lupus familis
XP_537486
375
42096
K256
Y
K
K
K
I
S
S
K
E
E
M
S
L
S
T
Cat
Felis silvestris
Mouse
Mus musculus
Q9JHK5
350
39882
S231
F
F
C
E
E
N
S
S
D
D
D
V
I
L
R
Rat
Rattus norvegicus
Q4KM33
350
39977
S231
F
F
C
E
E
N
S
S
D
D
D
I
I
L
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512767
334
37917
S215
F
F
C
E
D
N
S
S
D
D
D
V
V
L
K
Chicken
Gallus gallus
NP_990194
353
40280
S233
F
F
C
E
G
N
S
S
D
D
D
V
V
L
K
Frog
Xenopus laevis
NP_001080021
289
33430
G204
I
S
K
N
A
A
Q
G
L
A
E
T
T
L
L
Zebra Danio
Brachydanio rerio
NP_957135
352
40176
S231
F
F
C
E
G
Y
S
S
D
E
D
V
I
M
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781827
375
42698
S230
L
K
N
V
L
D
S
S
D
S
S
S
S
D
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
99.1
36
N.A.
92
92
N.A.
80.5
81.5
63.1
67.3
N.A.
N.A.
N.A.
N.A.
34.4
Protein Similarity:
100
100
100
55.7
N.A.
96.8
97.1
N.A.
89.4
90.6
73.7
83.8
N.A.
N.A.
N.A.
N.A.
53.3
P-Site Identity:
100
100
100
6.6
N.A.
93.3
93.3
N.A.
86.6
86.6
6.6
73.3
N.A.
N.A.
N.A.
N.A.
20
P-Site Similarity:
100
100
100
46.6
N.A.
100
100
N.A.
100
93.3
13.3
86.6
N.A.
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
10
10
0
0
0
10
0
0
0
0
0
% A
% Cys:
0
0
73
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
10
10
0
0
82
64
73
0
0
10
0
% D
% Glu:
0
0
0
73
46
0
0
0
10
19
10
0
0
0
0
% E
% Phe:
73
73
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
19
0
0
10
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
10
0
0
0
10
0
0
0
0
0
0
10
55
0
0
% I
% Lys:
0
19
19
10
0
0
0
10
0
0
0
0
0
0
64
% K
% Leu:
10
0
0
0
10
0
0
0
10
0
0
0
10
73
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
10
0
0
10
0
% M
% Asn:
0
0
10
10
0
64
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% R
% Ser:
0
10
0
0
0
10
91
82
0
10
10
19
10
10
10
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
10
10
0
10
% T
% Val:
0
0
0
10
0
0
0
0
0
0
0
64
19
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _